A review: In vivo studies of bioceramics as bone substitute materials

Abstract The critical size of bone defects resulting from disease or fractures is a medical problem, usually unable to repair spontaneously by the body's healing mechanisms. Bioceramics are being used for tissue regeneration stimulate growth cells and guide osseous remodeling. three most common types bioceramics in engineering (hydroxyapatite, bioactive glass, tricalcium phosphate) were selected studied vivo animal models, exhibiting favorable formation with positive biocompatibility reactions several models. In study, an extensive review research was conducted assess bone‐forming capabilities scaffolds remodeling vivo. This aims support large‐scale assessment studies generate optimal regenerative process based on analysis results. addition providing essential reference applications engineering, will assist developing novel investigations.